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Both transferrin and lactoferrin conjugated SPIONs surpass many clinical agents and enable the detection of submillimeter tumor foci (137, 138)

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- magnesium proposed mechanism magnesium blocks the NMDA receptor channels in the spinal cord and thus limits the influx of calcium ie reduces the risk of excitotoxicity and consequent exacerbation of pain

Overall, there were no differences observed between dose groups, but statistical power was limited due to the small sample size in this study

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